The Spontaneously Diabetic Torii (SDT) fatty rat is a new model for obese type 2 diabetes.The aim of the present study was to investigate the effect of 1/2 nephrectomy (Nx) on renal function and morphology and on blood pressure in SDT fatty rats.Male SDT fatty rats underwent 1/2 Fetish Nx or a sham operation (Sham).
Subsequently, animals were studied with respect to renal function and histological alterations.Induction of 1/2 Nx in SDT fatty rats led to functional and morphological damage to the remnant kidney and to hypertension, which are considered main characteristics of chronic Dog Crate kidney disease, at a younger age compared with the sham group.In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.